Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.

نویسندگان

  • Bogdana Krivogorsky
  • Peter Grundt
  • Robert Yolken
  • Lorraine Jones-Brando
چکیده

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 12  شماره 

صفحات  -

تاریخ انتشار 2008